As our understanding of disease advances, traditional clinical trial designs are becoming less and less viable. Two innovations in this area – the Umbrella trial and the Bucket (or Basket) trial – allow researchers to assess the safety and efficacy of new targeted drugs more efficiently. In addition, adaptive trial design offers the possibility to amend the clinical study protocol to reflect new insights or research data while the study is still ongoing. These innovations, which are all being used by Roche, allow us to bring new medicines to patients as fast and as efficiently as possible. http://www.roche.com/clinical_trials.htm

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